WebJul 8, 2024 · Small-cell neuroendocrine cancers (SCNCs) are an aggressive cancer subtype. Transdifferentiation toward an SCN phenotype has been reported as a resistance route in response to targeted therapies. Here, we identified a convergence to an SCN state that is widespread across epithelial cancers and is as … WebAug 9, 2024 · Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Pearson JD et al. Cancer Cell. 2024 08 09; 39 (8):1115 …
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WebJan 26, 2024 · In this review, we highlight the role of TEADs in cancer, discuss various avenues through which TEAD activity can be inhibited, and outline the opportunities for the administration of TEAD inhibitors. ... Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Cancer Cell (2024) F. … WebHome: Cell Press
WebSep 24, 2024 · The YAP off class consisted of virtually all blood cancers (leukemia, lymphoma, and myeloma), many neural cancers (retinoblastoma, low-grade glioma, … WebSep 22, 2024 · The binary cancer groups exhibit distinct YAP-dependent adhesive behavior and pharmaceutical vulnerabilities, underscoring clinical relevance. …
WebJul 16, 2024 · The researchers hope by deducing common vulnerabilities of these types of cancer, it may be possible to develop new therapeutic approaches and improve patient outcomes. More information: Joel D.... WebAug 1, 2024 · Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAP or …
WebMar 30, 2024 · Sorted in a descending order, distinct differences were found for the prevalence of different cancer types and histograms roughly show a power-law (long-tail) distribution trend. That is, a few cancer types at the head occupy the majority of the sample, while many categories at the tail occupy only a small portion of the total sample.
WebBinary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/ TEAD activity Graphical abstract Highlights d YAP/TAZ silencing in multiple … pool king south county moWebOur current primary focus is on cancer lineage plasticity, a phenomenon whereby cancer cells reprogram themselves to an alternative lineage or phenotypic state in order to adapt to selective pressures. ... Wikenheiser-Brokamp, K.A., Knudsen, E.S., Witkiewicz, A.K., Wrana, J.L., Goodrich, D.W., Bremner, R. Binary pan-cancer classes with distinct ... sharecare mailing addressWebSep 24, 2024 · Features and mechanisms underlying binary YAP on and YAP off cancer superclasses. (a) Features of YAP/TAZ-deficient (YAP off) and YAP/TAZ-positive (YAP on) cancer classes, including the types, genetic and phenotypic characteristics, and key vulnerabilities.(b) Opposite anti- versus pro-oncogenic YAP/TEAD functions in YAP off … sharecare ncqaWebBinary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu … sharecare medical records numberWebCancer Cell, Volume 39 Supplemental information Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity Joel D. Pearson, Katherine Huang, Marek Pacal, Sean R. McCurdy, Suying Lu, Arthur Aubry, Tao Yu, Kristine M. Wadosky, Letian Zhang, Tao Wang, Alex sharecare medical records contact numberWebAug 9, 2024 · Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Joel D. Pearson, Katherine Huang, Marek Pacal, Sean R. McCurdy, ... Rod Bremner. Pages 1115-1134.e12 Download PDF. Article preview. sharecare nashville tnWebJul 15, 2024 · Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. … pool kings tv show episodes